It's not a very feminine sounding appellation. When someone yells, "Hey, Junior!", you don't immediately think, "I wonder if she's pretty?". You're more apt to think, "Why is Bubba yelling at Jim Bob?".
Goose Island is an actual place in the North Branch of the Chicago River. It was there before there was a brewpub. The S.E. edge borders Cabrini-Green ("Good Times").