Probably, but not necessarily.... I don't think Luanne the character ever died, even though her VA did. One option, since this is set pretty far in the future from the original series, is to have another VA voice her.... or she could be written out of the show somehow.
Oh yeah, Tom Petty who voiced Lucky is also dead.... maybe Hank and Peggy could raise the orphan child, maybe the kid is about the same age Bobby was in the original series.