Yes.
Even if she hates the ocean, you can't go wrong with the St Regis Monarch Bay Resort. It's about as top shelf (and expensive) as you can get, but it's absolutely beautiful. It's in Dana Point at the bottom of Orange County.
Palm Springs is the go to getaway for the rich and famous. But, with Indian gaming a thing, places like Marongo in Cabazon and Pechanga in Temecula (between Riverside and San Diego) are all inclusive resorts they are fine for a weekend escape. Something more historic is the Mission Inn in Riverside. You wouldn't expect anything nice in RTown, so it's something of a surprise if you're not familiar with it.
The local mountains aren't much for resorting, especially in the summer. But, Lake Arrowhead is quaint.
And, if you like cheesy, there's Solvang to the North, above Santa Barbara.