Well, it's more than that even though you're absolutely correct about women (especially those of color) being villianized for it disproportionately. JPS is often seen as an imposter (also in large part because of her skin color), and it isn't helped that her relative lack of personality makes her seem cold. On top of that, her whole connection with Tupac Shakur rubs a lot of people the wrong way, giving them the perception that she's a social climbing hack. It's not all her fault, but she also doesn't do much to make herself likable. People like her are easy to target and it's understandable that Will might have felt some shame that he hadn't done more to protect her from Rock's crass joke. It's just unfortunate that his inappropriate response only made things worse by giving a shitty comedian cover for a clearly insulting joke.