That's the case for SAC. For the new Arise universe, I believe she was placed into a cyberbody at or near birth, so she lived her entire life cyberized. The '95 film and manga never really go into specifics, as I recall, but it's been a while since I thumbed through it.
Motoko has expressed misgivings, or understood the drawbacks of living in a cyberized body, but I can never recall her "holding a grudge" or "wanting revenge."
I would be fine if they tweaked themes, or moved some things around. What I don't like is the idea of so drastically changing a character's motivations, simply because the writer seems to be a hack who's following the contemporary big budget Hollywood playbook.