No, because the show is funny and I watch it to get away from that bullshit, so the fandom that wants to drag that in is terrible. Star's humor is reminiscent of Rocko at points, which is an immense compliment. Do not ruin that with non-existent subtext.
Also, the last episode was literally about a demon curse telling people Marco's deepest insecurities. He didn't say a damn thing about being transgender, so guess what? Theory debunked.